Aluminum Hydroxide Adjuvants Activate Caspase-1 and Induce IL-1 and IL-18 Release
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Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release.
Aluminum hydroxide (Alum) is the only adjuvant approved for routine use in humans, although the basis for its adjuvanticity remains poorly understood. In this study, we show that Alum activates caspase-1 and induce secretion of mature IL-1beta and IL-18. Human PBMC or dendritic cells stimulated with pure TLR4 and TLR2 agonists released only traces of IL-1beta or IL-18, despite the fact that the...
متن کاملThe Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism.
Aluminum adjuvants are widely used in human vaccines based on their ability to enhance antibody production. However, the mechanisms underlying these effects remain unknown. In the present study we assessed the direct in vitro effect of aluminum hydroxide on human peripheral blood monocytes, specifically with regard to its impact on the phenotype and functional properties of this cell population...
متن کاملThe Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.
Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase-1 activation and IL-1beta secretion, but the cellular pathways involved remain elusive. Here we report that the release of IL-1beta triggered by alum is abrogated in macrophages deficient in t...
متن کاملCutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.
Alum is the only adjuvant approved for routine use in humans, although the basis for its adjuvanticity remains poorly understood. We have recently shown that alum activates caspase-1 and induces secretion of mature IL-1beta and IL-18. In this study we show that, in human and mouse macrophages, alum-induced secretion of IL-1beta, IL-18, and IL-33 is mediated by the NLR (nucleotide-binding domain...
متن کاملModulation of NALP3 Inflammasome Genes by Estrogen
Immunity is known to be sexually dimorphic. This dimorphism may be attributed to the action of different hormones. Aluminum is a component of several vaccines and acts as an adjuvant of immunogenicity. The activation of the Nalp3 inflammasome plays a role in aluminum’s adjuvancy. Estrogen affects immune cells by regulating the expression of genes involved in immune-related mechanisms; such as t...
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تاریخ انتشار 2007